Mechelen is a wonderful place to start finding out about the life of Emperor Charles V. Lying between Brussels and Antwerp, it is readily accessible and everywhere in the central area is easily walkable. From the main square (Grote Markt) go to Keiserstraat, where you will find the Palace of Margaret of York and the Palace of Margaret of Austria. It was in these two buildings that Charles spent much of his early life - where he was educated, experienced life in the Burgundian court and was introduced to the art of government.
For more details go to the Mechelen page of the website.Another useful site: Visit Flanders
The Palace of Margaret of Austria
The Palace of Margaret of York